The Ecology and Evolutionary Biology Department has been working hard and monitoring, as well as planning, for COVID-19/Coronavirus and the safety of the UCLA community. We understand that we live in very uncertain times and with news about the virus changing frequently, we appreciate your cooperation. Please know the department is committed to working in everyone’s best interest—students, faculty, staff, and community at large.

October 13, 2021

12:00pm, PST 158 HH and Zoom

Kirk Lohmueller
UCLA, Dept of EEB

" Causes and Evolutionary Consequences of Recessive Deleterious Variation "

Many mutations that occur in genomes are deleterious, resulting in a decrease in reproductive fitness. In this talk, I will highlight our recent and ongoing work on deleterious variation in natural populations, with a specific emphasis on recessive deleterious variation. First, I will describe how we estimate both fitness effects and dominance effects of new mutations by combining genetic variation data from outcrossing and selfing species of Arabidopsis, and develop a new model for the evolution of dominance. Second, I will present our ongoing work to assess the validity of population genetic inferences of selection and dominance using historical records of mortality among offspring of close relatives. Third, I will describe how inbreeding depression from recessive deleterious mutations can enhance probability of extinction of small populations that descended from ancestrally larger populations. Lastly, I will show how recessive deleterious mutations can confound inference of adaptive introgression from genomic data. I will close by previewing how we are using this signal to infer the dominance of deleterious mutations in the human genome.


Seminar will be presented live, in-person, in

Hershey Hall, Room 158


Seminar will also be live-streamed via Zoom

Host: Jamie Lloyd-Smith