Seminars

The Ecology and Evolutionary Biology Department has been working hard and monitoring, as well as planning, for COVID-19/Coronavirus and the safety of the UCLA community. We understand that we live in very uncertain times and, with news about the virus changing frequently, we appreciate your cooperation. Please know the department is committed to working in everyone’s best interest—students, faculty, staff, and community at large.

With this, our Fall 2021 Seminar Series will be held in-person and virtually.

We appreciate your understanding at this time.

May 19, 2021

1:00pm Zoom Webinar

Paul Turner
Yale University

" Leveraging Evolutionary Trade-Offs and Phage Selection Pressure to Reduce Bacterial Pathogenicity "

Increasing prevalence and severity of multi-drug-resistant bacterial infections require novel management strategies. One possible strategy is a renewed approach to ‘phage therapy,’ where these administered viruses not only kill the target bacteria, but also predictably select for phage resistance that reduces virulence and/or increases antibiotic sensitivity (evolutionary trade-offs). By utilizing virulence factors as receptor binding sites, the phages exert selection for bacteria to evolve phage resistance by modifying (or losing) the virulence factor, potentially reducing bacterial pathogenicity. We present examples of phages that utilize bacterial lipopolysaccharides, efflux-pump proteins, and pili as binding sites, to kill target bacteria while selecting for phage resistance that coincides with useful clinical traits such as antibiotic re-sensitization and reduced tissue inflammation. These in vitro observations are compared to phenotypic, genetic and metagenomics analyses of microbes isolated longitudinally from patient samples before, during and after emergency phage therapy treatments. Throughout, emphasis is placed on the ability to accurately predict how target bacterial pathogens will respond to phages administered either alone, sequentially, or in mixtures (cocktails).

Wednesday, May 19, 2021*

please note the time of seminar

1pm

Via Zoom


Host: Ashlyn Ford