Kirk Lohmueller

Assistant Professor

email:   KLOHMUELLER@UCLA.EDU
phone:  (310)-825-7636
office:  BOX 951606 4312 LIFE SCIENCES
[website]



Recent Courses


Education

BS, Biology, Georgetown University 2005
PhD, Genetics & Development (biometry Minor), Cornell University 2010



Research Interests

My research focuses on population genetics and genomics. I develop and implement computational approaches to interpret genetic variation data to learn about evolution and disease. Specifically, I am interested in understanding how natural selection has shaped patterns of genetic variation across the genome and in different species, as well as the role that population history has played in this process. Additionally, I use genetic variation data to learn about population history. Finally, I am exploring how population genetic approaches can contribute to finding genes responsible for complex traits.

My group combines the development of new computational methods with the analysis of cutting-edge genomic data. In both cases, our work relies heavily on population genetic models.


Selected Publications

Haned, H., P. Gill, K. Lohmueller, K. Inman, N. Rudin, "Validation of probabilistic genotyping software for use in forensic DNA casework: Definitions and illustrations", Science and Justice, 56 : 104-108 (2016) [link].

Phung, T.N., C.D. Huber, K.E. Lohmueller, "Determining the effect of natural selection on linked neutral divergence across species", PLoS Genetics, 12 : e1006199- (2016) [link].

Ortega-Del Vecchyo, D., C.D. Marsden, K.E. Lohmueller, "PReFerSim: Fast simulation of demography and selection under the Poisson Random Field model", Bioinformatics, 12 : - (2016) [link].

Robinson, J.A., D. Ortega-Del Vecchyo, Z. Fan, B.Y. Kim, B.M. vonHoldt, C.D. Marsden, K.E. Lohmueller, R.K. Wayne, "Genomic flatlining in the endangered island fox (Urocyon littoralis)", Current Biology, 26 : 1183-1189 (2016) [link].

Marsden, C.D., N. Rudin, K. Inman, K.E. Lohmueller, "An assessment of the information content of likelihood ratios derived from complex mixtures", Forensic Sci Int Genet, 22 : 64-72 (2016) [link].

Marsden, C.D., D.. Ortega-Del Vecchyo, D.P. O'Brien, J.F. Taylor, O. Ramirez, C. Vila, T. Marques-Bonet, R.D. Schnabel, R.K. Wayne, K.E. Lohmueller, "Bottlenecks and selective sweeps during domestication have increased deleterious genetic variation in dogs", Proc Natl Acad Sci USA, 113 : 152-157 (2016) [link].

Brown, R., H. Lee, A. Eskin, G. Kichaev, K.E. Lohmueller, B. Reversade, S.F. Nelson, B. Pasaniuc, "Leveraging ancestry to improve causal variant identification in exome sequencing for monogenic disorders", Eur J Hum Genet, 24 : 113-119 (2016) [link].

Rohlfs, R.V., V.R. Aguiar, K.E. Lohmueller, A.M. Castro, A.C. Ferreira, V.C. Almeida, I.D. Louro, R. Nielsen, "Fitting the Balding-Nichols model to forensic databases", Forensic Sci Int Genet, 19 : 86-91 (2015) [link].

Kim, B.Y., K.E. Lohmueller, "Selection and reduced population size cannot explain higher amounts of Neandertal ancestry in East Asian than in European human populations", Am J Hum Genet, 96 : 454-461 (2015) [link].

Inman, K., N. Rudin, K. Cheng, C. Robinson, A. Kirschner, L. Inman-Semerau, K. E. Lohmueller, "Lab Retriever: a software tool for calculating likelihood ratios incorporating a probability of drop-out for forensic DNA profiles", BMC Bioinformatics, 16 : 298- (2015) [link].