James                          Lloyd-Smith

James Lloyd-Smith

Professor

email:   jlloydsmith@ucla.edu
phone:  310-206-8207
office:  Terasaki Life Sciences Building 4135
lab:  Terasaki Life Sciences Building 4000
[website]



Recent Courses

BIOMATH 596 - Directed Individual Study or Research in Biomathematics
EE BIOL 201 - Introduction to R for Ecology and Evolutionary Biology
EE BIOL 596 - Directed Individual (or Tutorial) Studies


Education

B.Sc.(Hon), Physics And Chemistry, Queen's University 1996
M.Sc., Physics, University of British Columbia 1999
PhD, Biophysics, University of California, Berkeley 2005



Research Interests

I study the ecological and evolutionary dynamics of infectious disease in animal and human populations, and at the animal-human interface where novel human pathogens such as SARS or pandemic influenza can emerge. By combining theoretical models with data, I aim to deepen our understanding of fundamental principles of disease transmission and adaptation, and apply those principles to interpret observed patterns, uncover driving mechanisms, and design effective control policies. I work on a diverse range of disease-host systems, including leptospirosis in California sea lions, monkeypox in humans and wildlife in central Africa, and influenza and other emerging diseases in human populations.


Selected Publications

Lloyd-Smith, J.O., "Predictions of virus spillover across species", Nature, 546 : 603-604 (2017) .

Buhnerkempe, M.G., K. C. Prager, Strelioff, C.C., Greig, D.J., Laake, J.L., Melin, S.R., DeLong, R.L., Gulland, F.M.D., Lloyd-Smith, J.O., "Detecting signals of chronic shedding to explain pathogen persistence: Leptospira interrogans in California sea lions as a case study", Journal of Animal Ecology, 86 : 460-472 (2017) .

Pepin, K.M., Kay, S.L., Golas, B.D., Shriner, S.S., Gilbert, A.T., Miller, R.S., Graham, A.L., Riley, S., Cross, P.C., Samuel, M.D., Hooten, M.B., Hoeting, J.A., Lloyd-Smith, J.O., Webb, C.T., Buhnerkempe, M.G., "Inferring infection hazard in wildlife populations by linking data across individual and population scales", Ecology Letters, 20 : 275-292 (2017) .

Gostic, K.M., Ambrose, M.R., Worobey, M, Lloyd-Smith, J.O., "Do maternal antibodies facilitate hemagglutinin imprinting to influenza A viruses encountered early in childhood?", bioRxiv, 110981 : - (2017) [link].

Gostic, K.M., Ambrose, M.R., Worobey, M, Lloyd-Smith, J.O., "Maternal antibodies' role in protection - response", Science, 355 : 705- (2017) .

Lipsitch, M., Barclay, W., Raman, R., Russell, C.J., Belser, J.A., Cobey, S., Kasson, P.M., Lloyd-Smith, J.O., Maurer-Stroh, S., Riley, S., Beauchemin, C.A.A., Bedford, T., Friedrich, T.C., Handel, A., Herfst, S., Murcia, P.R., Roche, B., Wilke, C., Russell, C.A., "Viral factors in influenza pandemic risk assessment", eLife, 5 : e18491- (2016) .

Gostic, K.M., Ambrose, M.R., Worobey, M, Lloyd-Smith, J.O., "Potent protection against H5N1 and H7N9 influenza via childhood hemagglutinin imprinting", Science, 354 : 722-726 (2016) .

Wu, N.C.*, Dai, L.*, Olson, C.A., Lloyd-Smith, J.O., Sun, R., "Adaptation in protein fitness landscapes is facilitated by indirect paths", eLife, 5 : e16965- (2016) .

, "Challenges in modelling infectious disease dynamics", Epidemics, Lloyd-Smith, J.O., Mollison, D., Metcalf, C.J.E., Klepac, P., Heesterbeek, J.A.P.(Eds.), 10 : - (2015) .

Buhnerkempe, M.G., Gostic, K.M., Park, M., Ahsan, P., Belser, J.A., Lloyd-Smith, J.O., "Mapping influenza transmission in the ferret model to transmission in humans", eLife, Lloyd-Smith, J.O., Mollison, D., Metcalf, C.J.E., Klepac, P., Heesterbeek, J.A.P.(Eds.), 4 : e07969- (2015) .