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email:  jnovembre@ucla.edu
phone:  (310)825-4065
office:  LIFE SCIENCE BLDG 4325
lab:  
homepage:  http://www.eeb.ucla.edu/Faculty/Novembre

research interests:  Computational methods in population genetics; human evolutionary genetics; genome evolution; population structure and adapation

Education

B.A., Biochemistry, The Colorado College 2000
Ph.D., Computational Biology / Genomics, University of California-Berkeley 2006
Postdoc, Statistical Genetics / Human Population Genetics, University of Chicago 2007

Research Interests

My research lies at the interface of population genetics and computational statistics. Specifically, projects focus on developing and evaluating statistical methods for analyzing genomic-scale population genetic data. Much of this work investigates human evolutionary history using data from emerging genotyping and sequencing technologies, although other projects address evolutionary genetic questions in non-human, non-model organisms. One central area of current interest is in computational methods to study relatedness among populations and the applications these methods have for detecting natural selection, genome-wide association mapping, understanding population history, personal ancestry inference in humans, and conservation genetics. Most broadly, I am interested in how to decipher patterns of observed genetic variation to understand evolutionary, genomic, and ecological processes.

Selected Publications

Auton, A., Byrc, K., Boyko, A.R., Lohmueller, K.E., Novembre, J., Reynolds, A., Indap, A., Wright, M.H., Degenhardt, J., Gutenkunst, R.N., King, K.S., Nelson, M.R. and Bustamante, C.D.. 2009. Global distribution of genomic diversity underscores rich complex history of continental human populations Genome Research 19: 795-803 .

Pickrell, J.K., Coop, G., Novembre, J., Kudaravalli, S, Li, J., Absher, D., Srinivasan, B., Barsh, G.S., Myers, R.M., Feldman, M.W., and Prichard, J.K.. 2009. Signals of recent positive selection in a worldwide sample of human populations Genome Research 19: 826-837 .

Coop, G., Pickrell, J.K., Novembre, J., Kudaravalli, S., Li, J., Absher, D., Myers, R.M., Cavalli-Sforza, L.L., Feldman, M.W. and Pritchard, J.K.. 2009. The role of geography in human adaptation PloS Genetics 5: e1000500 .

Novembre, J. and Slatkin, M.. 2009. Likelihood-based inference in isolation-by-distance models using the spatial distribution of low-frequency alleles Evolution 63: 2914-2925 .

Alexander, D.H., Novembre, J. and Lange, K.. 2009. Fast model-based estimation of ancestry in unrelated individuals Genome Research 19: 1655-1664 .

Novembre, J. and di Rienzo, A.. 2009. Spatial patterns of variation due to natural selection in humans Nature Reviews Genetics 10: 745-755 .

Novembre, J. and Stephens, M.. 2008. Interpreting principal components analyses of spatial population genetic variation Nature Genetics 40: 646-649 .

Reiner, A.P., Barber, M.J., Guan, Y., Ridker, P.M., Lange, L.A., Chasman, D.I., Walston, J.D., Cooper, G.M., Jenny, N.S., Rieder, M.J., Durda, J.P., Smith, J.D., Novembre, J., Tracy, R.P., Rotter, J.I., Stephens, M., Nickerson, D.A. and Krauss, R.M.. 2008. Polymorphisms of the HNF1A Gene Encoding Hepatocyte Nuclear Factor-1alpha are Associated with C-Reactive Protein American Journal of Human Genetics 82: 1193-1201 .

Nelson, M.R., Bryc, K., King, K.S., Indap, A., Boyko, A.R., Novembre, J, Maruyama, Y., Waterworth, D.M., Waeber, G., Vollenweider, P., Oskenberg, J.R., Hauser, S.L., Stirnadel, H., Kooner, J.S., Chambers, J.C., Jones, B., Mooser, V., Bustamante, C.D., Rosed, A.D., Burns, D.K., Ehm, M.G. and Lai, E.H.. 2008. The Population Reference Sample (POPRES): a resource for population, disease, and pharmacological genetics research American Journal of Human Genetics 83: 347-358 .

Novembre, J., Johnson, T., Bryc, K., Kutalik, Z., Boyko, A.R., Auton, A., Indap, A., King, K.S., Bergman, S., Nelson, M.R., Stephens, M. and Bustamante, C.D.. 2008. Genes mirror geography within Europe Nature 456: 98-101 .