January 27 2011

10:00 LSB 2320

This seminar is sponsored by The Departments of Ecology & Evolutionary Biology and Microbiology, Immunology, & Molecular Genetics

Pamela Yeh
Biology Department, Portland State University

Evolution of Bacteria in Multi-Drug Environments


The evolution of antibiotic resistant bacteria is an urgent and global public health threat. In my seminar, I will first show how we can use networks of drug interactions to determine the mechanism of action of new antibiotics and unknown compounds. Second, I will show how and why certain types of drug combinations may be better at slowing the evolution and spread of antibiotic resistant pathogens. Together these results will help our understanding of bacterial response to environmental perturbations and the maintenance of phenotypic diversity. Finally I will conclude by highlighting future work to examine how human impacts, such as urbanization and antibiotic use in agriculture, affect the evolutionary trajectory of both birds and bacteria and their interactions.















































































































































































































































































































































































































































































































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