May 22 2018

12:00 158 Hershey Hall

This seminar is sponsored by QCB and EEB

Aaron King

Pertussis resurgent: why incidence is rising and why the accepted explanation is both compelling and wrong


Aaron King
Department of Ecology and Evolutionary Biology
University of Michigan

Sponsored by the Department of Ecology and Evolutionary Biology and the Institute for Quantitative and Computational Biosciences

The current resurgence of pertussis in several countries with high vaccine coverage has resulted in incidence levels and infant mortality not witnessed since the 1950s. The underlying causes have been the subject of much speculation, with particular attention paid to the shortcomings of the latest generation of vaccines. In this talk, I review recent work that extracts information from the dynamics of the disease as revealed in long time series of incidence records. We formulate nonlinear, stochastic transmission models expressing competing hypotheses as to vaccine properties and challenge them to explain 16 years of highly-resolved age-specific incidence data. Our results suggest that the resurgence of pertussis is best understood as the end of the honeymoon periodthe predictable consequence of a long history of incomplete vaccine coverage. We find strong evidence that current acellular vaccines induce protection that is both more effective and durable, in contrast to the conventional wisdom, which holds that vaccine-induced immunity wanes very rapidly. Finally, we demonstrate that the evidence that has been adduced in favor of the conventional view is itself entirely consistent with our findings.

Tuesday, May 22, 2018
12:00 noon
Hershey Hall Grand Salon, Room 158

























































































































































































































































































































































































































































































































































































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