February 19 2019

Division of Life Sciences Mentor Professor Colloquium

Claudio Villaneuva, PH.D
Department of Biochemistry
University of Utah

“Tales from the Cold: Mechanisms of Thermogenesis and the Impact on Metabolism”

Cold adaptation requires an understanding of how cells communicate to orchestrate a metabolic response to promote thermogenesis. As the -omics era has provided tremendous opportunities to delve deep into genomics, transcriptomics, and more recently proteomics; lipidomics stands out as one that is composed of tremendous diversity, yet with little understanding on the impact on physiology and disease. Our lab has set out to understand the changes in the plasma lipidome in conditions of cold stress, and test the impact on systemic energy metabolism. Through these studies we identified several hundred lipids that change in response to the cold. We uncovered a previously unrecognized role for acylcarnitines, a mitochondrial-derived lipid, that promotes adaptive thermogenesis. Our studies show that adipose tissue lipolysis signals to the liver to activate the nuclear receptor HNF4, a lipid sensing transcription factor that regulates lipid handling in the liver. These studies also uncovered a role for the white adipose tissue in generating lipid signals that drive changes in the metabolic transcriptional program in the liver. Together, our studies highlight how intercellular communication is essential in regulating thermogenesis in mammals.

Tuesday, February 19, 2019
12:00 Noon
158 Hershey Hall

Host: Ketema Paul
Refreshments will be served

February 21 2019

Institute of the Environment and Sustainability: Hollywood for Science Gala

February 21st, 2019

Celebrate with the biggest names in Hollywood at the 2019 IoES Gala. Together, we can move science to action.

As the world grapples with escalating challenges such as climate change, pollution and deforestation, UCLA is taking decisive action. Global leaders in philanthropy, entertainment and business will again come together to support that action at the 2019 Hollywood for Science Gala, which supports UCLA’s Institute of the Environment & Sustainability (IoES).

Honoring: Barbara Streisand & Gisele Bündchen

Hosted by Milutin Gatsby, Global Fundraising Chairman
Lawrence Bender
Alexandria Jackson

Event Chairs:
Jennifer Aniston
Orlando Bloom
Gerard Butler
Isabelle Bscher
Courteney Cox
Nina Doorbell
Laurence Fishburne
Isabeli Fontana
Andy Garcia
Toni Garrn
Jeff Goldblum
Goldie Hawn
Tiffany Haddish
Taylor Hill
Cheryl Hines
Anjelica Huston
Milla Jovovich
Bobby Kennedy Jr.
Olga Kurylenko
Lyn Lear
Norman Lear
Eva Longoria
Adriana Lima
Angela Lindvall
Nadine Leopold
Maryna Linchuk
Meg Ryan
Sofia Resing
Caroline Scheufele
Robin Thicke
Chris Tucker
Veronica Varekova
Devon Windsor

Presented by Chopard

Special performances by surprise guests

Auction conducted by Simon de Pury

After Party by Richie Akiva 1 Oak

Ticket sales will be available soon. Until then, please contact IoESgala@support.ucla.edu with any questions.

Request an RSVP here, and see ticket & table prices

March 1 2019

Volunteer to be a Docent!

Do you love plants? Deepen your knowledge + give back to the
community: become a volunteer docent!

The UCLA Botanical Garden is an incredible 7.5 acre living museum, containing plants from all
over the world! Come learn to interpret this natural wonder for visitors. Training time will be a
combination of short lectures, garden walks, educational strategy practice, and development
of a personalized tour that you can confidently deliver to k-12 students and adults.

• Support the educational mission of the Garden
• Learn more about plants
• Meet new friends
• Strengthen your public speaking skills
• Attend docent appreciation events and trips

January 18th - March 1st 2019
We will meet for 6 Friday afternoons (1-3pm):
1/18, 1/25, 2/1, 2/8, 2/22, 3/1. There will also be
homework and practice to do outside of those dates. You will need to deliver an
hour-long practice tour to become a garden
docent-don't worry, we'll help you create it!

Interested? Email Jules for more information: julesc@ucla.edu

March 4 2019

What does it mean to replicate studies in a cultural species?

Monday, March 4th, 2019
352 Haines Hall

Dan Hruschka
Arizona State University

Replicating a study among our fellow humans requires a researcher to interact with study participants according to protocols that are comparable with previous studies. However, thanks to humanity’s rich capacity for cultural learning, it can be challenging to identify what counts as a “comparable protocol” across different human groups. Specifically, diverse culturally learned capacities, motivations, symbolic connections, and expectations for appropriate social interactions can make some protocols impossible to implement directly across cultures while rendering the results of other “workable” protocols nearly impossible to interpret. I used examples from our work studying the social determinants of giving to illustrate: (1) the extent of this problem, and (2) how overcoming such challenges can tell us about our tacit models of how humans should think and behave. In this way, such efforts at translation are not just a methodological exercise, but can also inform our models of human psychological and behavioral diversity.

March 5 2019

Single-Cell RNA-SEQ Analysis: A New Interactive Workshop from the Collaboratory

Yerbol Kurmangaliev, Ph.D
Igor Mandric, Ph.D

March 5-7, 2019
Register to Attend

QCB Collaboratory presents a two-day workshop ideal for life science and biomedical researchers, bioinformaticians, and students.
The Single-Cell RNA-Seq Analysis workshop provides an entry-level introduction to the basic concepts and data analysis tools for single-cell RNA-seq techniques.
For more information, click here

Yerbol & Igor will cover:
• Concept of scRNA-seq and main applications
• Important issues in experimental design
• Comparison between popular technical platforms
• Raw data processing
• Overview of scRNA-Seq analysis and logistics of Seurat
• Data preprocessing: loading, QC/filtering, normalization/scaling
• Dimensionality reduction and clustering
• Identification of marker genes
• Visualizations

March 11 2019

Evolutionary Retrospectives on the Human Life History Trajectory

Monday, March 11h, 2019
352 Haines Hall

Raziel Davison
University of California, Santa Barbara

We investigate human life history evolution by comparing smallscale subsistence societies and chimpanzees to identify the roles that fertility and mortality play in driving population-level fitness differences. We discuss differences in the selection pressures facing individuals of different ages and to make inferences about the trajectory of human life history evolution. Most human populations are growing but post-reproductive survival decouples population growth from lifespan, with high fertility driving rapid growth in some societies and low fertility balancing longevity to maintain near-stationarity in others. Chimpanzee declines are decoupled from fertility because mortality attrition limits higher potential fertility contributions. Selection pressures suggest that variable child survival likely regulated human population dynamics over evolutionary history and may reflect bet-hedging costs of high fertility, with quality/quantity trade-offs constraining the evolution of slower life histories. Common stationarity conditions may represent invariant allometry of chimpanzee and human life histories. Among humans, production and knowledge transfers constituting fitness contributions of post-reproductive adults part the veil of selection to favor long post-reproductive lifespans, but in chimpanzees transfers are limited and reproductive senescence tracks mortality closely.

March 12 2019

Protein-Protein Interactions

A New Interactive Workshop from the Collaboratory

Guest Instructor Lukasz Salwinski

March 12th & 13th, 9:00AM to 12:00PM
Register to Attend

March 12th: Experimental methods of protein interaction determination, protein-protein interaction resources, and interaction record formats.
March 13th: Retrieval & processing of interaction records, visualization of interaction data, and the role of protein interaction in the interpretation of large scale datasets.

QCB Collaboratory presents a two-day workshop ideal for life science and biomedical researchers, bioinformaticians, and students.
The Protein-Protein Interactions workshop covers experimental approaches to protein interaction determination; processing & presentation of interaction data available from online resources, and the role of interaction data in the interpretation of large scale datasets.
For more information, click here

March 23 2019

IoES: 2019 Conservation Genomics Workshop

UCLA La Kretz Center for California Conservation Science
March 23rd to March 27th, 2019

This annual workshop provides a comfortable, informal training environment for a small group of 20 motivated graduate students to explore how conservation problems can best be addressed with genomic-level data. Our goal is to provide hands-on experience in the efficient collection, troubleshooting, and analysis of large, genome-level data sets for conservation-relevant problems. We focus specifically on non-model systems, and how we can best study and protect endangered taxa with genomic approaches. One of the highlights of our workshop is active participation from members of several US and California governmental agencies who use actual genetic data in endangered species protection and management, providing a forum for exploring the most relevant aspects of conservation genomics to managers.

Course Highlights:
Genomics of non-model systems, and the applications of those data to applied conservation, change daily. RADseq, target capture, and whole-genome resequencing all have their place, and all provide technical and analytical challenges that we explore with hands-on tutorials. Equally important, we discuss how to make your analyses accessible and relevant to applied conservation scientists and administrators. We do this by inviting state and federal agency managers to discuss the ways in which they see genomics shaping conservation decision-making now and in the future. These interactions are foundational to our workshop, and provide insights into partnerships that achieve our primary goal: genomic science that helps conservation decision-makers.


click here for more information